DNA Sequence Context Conceals α-Anomeric Lesions

In vivo detection and replication studies of α-anomeric lesions of 2′-deoxyribonucleosides

DNA damage, arising from endogenous metabolism or exposure to environmental agents, may perturb the transmission of genetic information by blocking DNA replication and/or inducing mutations, which contribute to the development of cancer and likely other human diseases. Hydroxyl radical attack on the C1', C3' and C4' of 2-deoxyribose can give rise to epimeric 2-deoxyribose lesions, for which the...

Beyond mCG: DNA Methylation in Noncanonical Sequence Context

Variable Order Finite-Context Models in DNA Sequence Coding

Being an essential key in biological research, the DNA sequences are often shared between researchers and digitally stored for future use. As these sequences grow in volume, it also grows the need to encode them, thus saving space for more sequences. Besides this, a better coding method corresponds to a better model of the sequence, allowing new insights about the DNA structure. In this paper, ...

“Mild” COPD: What Spirometry Conceals!

PDNAsite: Identification of DNA-binding Site from Protein Sequence by Incorporating Spatial and Sequence Context

Protein-DNA interactions are involved in many fundamental biological processes essential for cellular function. Most of the existing computational approaches employed only the sequence context of the target residue for its prediction. In the present study, for each target residue, we applied both the spatial context and the sequence context to construct the feature space. Subsequently, Latent S...